Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.3K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.3K
Anatomy of the Ear01:16

Anatomy of the Ear

11.4K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
11.4K
Sustainable Development01:43

Sustainable Development

14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.0K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.0K
Language Development01:22

Language Development

880
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
880
Development of the Heart01:27

Development of the Heart

2.3K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroprotective potential of a TrkB-FL-derived cell-penetrating peptide in cochlear synaptopathy and noise-induced hearing loss.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Microbial tryptophan metabolites modulate blood-brain and gut barriers <i>in vitro</i>.

Neuroscience applied·2026
Same author

Automated real-time imaging of intestinal barrier integrity and molecular profiling for early outcome prediction in inflammatory bowel disease: endo-histo-barrier-omics study.

Journal of Crohn's & colitis·2025
Same author

NLRP3 inflammasome and hearing loss: from mechanisms to therapies.

Journal of neuroinflammation·2025
Same author

Quinolylnitrone 23 Protects from Auditory Cell Oxidative Injury and Noise-Induced Hearing Loss.

ACS pharmacology & translational science·2025
Same author

Gut microbiota regulates exercise-induced hormetic modulation of cognitive function.

EBioMedicine·2025

Related Experiment Video

Updated: Jan 26, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.0K

TGFβ2-induced senescence during early inner ear development.

Alejandro Gibaja1, María R Aburto1, Sara Pulido1,2

  • 1Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Madrid, Spain.

Scientific Reports
|April 13, 2019
PubMed
Summary

Cellular senescence, a process previously linked to aging and cancer, is essential for vertebrate inner ear development. Senescent cells appear in a specific pattern, influencing otic vesicle formation and differentiation.

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.5K
Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

10.0K

Related Experiment Videos

Last Updated: Jan 26, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.0K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.5K
Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

10.0K

Area of Science:

  • Developmental Biology
  • Cellular Biology
  • Otolaryngology

Background:

  • Embryonic development involves complex cellular programs like apoptosis, proliferation, and differentiation.
  • Cellular senescence is increasingly recognized as a crucial process in development, beyond its roles in aging and cancer.

Purpose of the Study:

  • To investigate the role and temporal pattern of cellular senescence during vertebrate inner ear development.
  • To understand the signaling pathways involved in senescence-mediated inner ear morphogenesis.

Main Methods:

  • Observation of senescent cell distribution in the developing vertebrate inner ear.
  • Analysis of apoptosis and proliferation markers in relation to senescence.
  • Experimental modulation of senescence and assessment of otic vesicle morphology.
  • Investigation of Transforming Growth Factor beta (TGFβ) and Insulin-like Growth Factor type 1 (IGF-1) signaling pathways.

Main Results:

  • Senescent cells are present in a regulated temporal pattern in the developing inner ear, specifically around the otic pore and endolymphatic duct.
  • Cellular senescence correlates with increased apoptosis and reduced proliferation during endolymphatic duct formation.
  • Disruption of senescence leads to abnormal otic vesicle morphology.
  • TGFβ and IGF-1 signaling pathways interact to regulate cellular dynamics crucial for inner ear development.

Conclusions:

  • Cellular senescence is a naturally occurring and essential process in early vertebrate inner ear development.
  • Senescence plays a key role in coordinating cellular dynamics, morphogenesis, and differentiation during inner ear formation.
  • The interplay between TGFβ and IGF-1 signaling is critical for senescence-mediated developmental processes in the inner ear.