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The Association between the Level of Antithrombin III and Mortality in Children with Sepsis

Indah Nur Lestari1, Chairul Yoel1, Munar Lubis1

  • 1Department of Child Health, Medical School, University of Sumatera Utara, Medan, Indonesia.

Open Access Macedonian Journal of Medical Sciences
|April 13, 2019
PubMed

Insights

This study found no significant link between antithrombin III levels and mortality in pediatric sepsis patients. Further research is needed to understand the role of this coagulation marker in sepsis prognosis.

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Infectious diseases

Background:

  • Sepsis poses a significant threat to children's health, impacting morbidity and mortality rates.
  • Accurate diagnosis and prognostic indicators for pediatric sepsis are crucial for effective treatment.
  • Antithrombin III is recognized as a potential biomarker for assessing sepsis prognosis.

Purpose of the Study:

  • To investigate the relationship between antithrombin III levels and mortality in children diagnosed with sepsis.
  • The study was conducted in the Pediatric Intensive Care Unit of Haji Adam Malik General Hospital, Medan.

Main Methods:

  • A cross-sectional study involving 41 pediatric sepsis patients was performed.
  • Sepsis diagnosis was based on clinical and laboratory findings, including complete blood count, antithrombin III, C-reactive protein, procalcitonin, and blood cultures.
  • The chi-square test was employed to analyze the association between antithrombin III levels and mortality.

Main Results:

  • A low antithrombin III level was observed in 31.7% of the children.
  • Children with low antithrombin III levels showed a trend towards higher mortality risk (PR = 2.473), though not statistically significant (P = 0.184).
  • The study found no statistically significant association between antithrombin III levels and mortality in pediatric sepsis cases.

Conclusions:

  • The current study did not establish a statistically significant link between antithrombin III levels and mortality in pediatric sepsis.
  • The prognostic value of antithrombin III in pediatric sepsis requires further investigation with larger cohorts.
Abstract

Keywords:
Antithrombin IIIChildrenMortalitySepsis

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