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Updated: Jan 26, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Atypical Manifestations in Classic Kaposi Sarcoma: Case Series of Two Patients HIV - Negative
Tiziana Peduto1, Francesco Cillo1, Paola Nappa1
1Department of Dermatology, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy.
Background:
Kaposi's sarcoma (KS) is a tumour of endothelial, blood and lymphatic cells, caused by an infection with human herpesvirus-8 (HHV-8). The skin lesions of KS, especially of the classical or Mediterranean variant (CKS), are represented by red-purple macules, plaques and nodules, localised mainly on the extremities.
Case Report:
This case series intend to describe multifocal atypical kaposian manifestations in two HIV negative subjects, affected by CKS, treated with successful chemotherapy.
Conclusions:
Although atypical manifestations are extremely rare events, we suggest an accurate, objective examination because a prompt diagnosis can lead to a vital intervention in the patient's health and sometimes to the identification of the disease itself.
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