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Related Concept Videos

Le Chatelier's Principle: Changing Temperature02:19

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Consistent with the law of mass action, an equilibrium stressed by a change in concentration will shift to re-establish equilibrium without any change in the value of the equilibrium constant, K. When an equilibrium shifts in response to a temperature change, however, it is re-established with a different relative composition that exhibits a different value for the equilibrium constant.
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Le Chatelier's Principle: Changing Concentration02:27

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A system at equilibrium is in a state of dynamic balance, with forward and reverse reactions taking place at equal rates. If an equilibrium system is subjected to a change in conditions that affects these reaction rates differently (a stress), then the rates are no longer equal and the system is not at equilibrium. The system will subsequently experience a net reaction in the direction of a greater rate (a shift) that will re-establish the equilibrium. This phenomenon is summarized by Le...
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Related Experiment Video

Updated: Jan 26, 2026

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
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Minimal change disease and malaria.

Neil Rangwani1, Sideris Facaros1, Joseph Wang2

  • 1Summa Health Systems, Akron, OH, USA.

Clinical Kidney Journal
|April 13, 2019
PubMed
Summary
This summary is machine-generated.

Severe malaria caused by Plasmodium falciparum can lead to acute renal failure. Prompt treatment of malaria and renal replacement therapy resulted in a full recovery for a patient with minimal change disease.

Keywords:
Plasmodium falciparumacute kidney injurymalariaminimal change diseaseproteinuria

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Area of Science:

  • Tropical medicine
  • Nephrology
  • Infectious diseases

Background:

  • Malaria, a Plasmodium parasite infection, presents with diverse clinical manifestations, including renal complications.
  • Minimal change disease is a cause of nephrotic syndrome, but its association with severe malaria is rarely reported.

Purpose of the Study:

  • To report a rare case of minimal change disease secondary to Plasmodium falciparum infection.
  • To highlight the link between severe malaria and acute renal failure requiring renal replacement therapy.

Main Methods:

  • Case presentation of a patient with malaria-induced minimal change disease.
  • Description of clinical course, laboratory findings, and treatment provided.
  • Discussion of the patient's recovery with antimalarial therapy and renal replacement therapy.

Main Results:

  • The patient developed nephrotic-range proteinuria and acute renal failure.
  • Renal replacement therapy was initiated due to severe kidney injury.
  • Full recovery was achieved following treatment of the malarial infection and sustained renal support.

Conclusions:

  • Plasmodium falciparum infection can trigger minimal change disease and severe renal impairment.
  • Early diagnosis and comprehensive management, including antimalarial treatment and renal replacement therapy, are crucial for favorable outcomes.
  • This case underscores the potential for severe malaria to cause significant renal damage necessitating long-term dialysis.