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Bordetella parapertussis Bacteremia: Clinical Expression and Bacterial Genomics

Julie Toubiana1,2,3, Saba Azarnoush4, Valérie Bouchez1

  • 1Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France.

Open Forum Infectious Diseases
|April 13, 2019
PubMed

Insights

Bordetella parapertussis rarely causes severe disease, but this study reports an unusual case of bacteremia. Genomic analysis compared this isolate to others from respiratory infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genomics

Background:

  • Whooping cough is primarily caused by Bordetella pertussis.
  • Bordetella parapertussis, a related species, typically causes milder illness.
  • Bacteremia due to B. parapertussis is uncommon.

Purpose of the Study:

  • To report an unusual case of B. parapertussis bacteremia.
  • To review existing literature on B. parapertussis infections.
  • To perform genomic characterization of the B. parapertussis isolate.

Main Methods:

  • Case report of bacteremia.
  • Literature review.
  • Whole-genome sequencing and comparative genomic analysis.

Main Results:

  • An unusual case of B. parapertussis bacteremia was identified.
  • Genomic sequencing revealed specific characteristics of the isolate.
  • Comparison with other B. parapertussis strains provided insights into genomic diversity.

Conclusions:

  • B. parapertussis can cause severe disease, including bacteremia, although rare.
  • Genomic analysis aids in understanding the pathogenicity and evolution of B. parapertussis.
  • Further research is warranted to elucidate the clinical significance of B. parapertussis genomic variations.
Keywords:
Bordetella parapertussisbacteremiachildrengenomics

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