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Related Experiment Video

Updated: Jan 26, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

A temporal and spatial map of axons in developing mouse prostate.

Anne E Turco¹, Mark T Cadena², Helen L Zhang³

¹Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI, USA.

Histochemistry and Cell Biology

|April 13, 2019

Summary

This summary is machine-generated.

Researchers mapped key nerve subtypes in developing mouse prostates, revealing their appearance and distribution patterns. This study provides a foundation for understanding prostate innervation and its changes during disease.

Keywords:

Axon development Mouse Parasympathetic Prostate innervation Sympathetic

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Area of Science:

Urology
Developmental Biology
Neuroscience

Background:

Prostate autonomic and sensory axons regulate gland function but are remodeled during disease.
Reawakened morphogenetic pathways may drive axon remodeling in prostate cancer and benign prostatic hyperplasia.
Knowledge gaps exist regarding developmental signaling pathways that guide prostate axon innervation.

Purpose of the Study:

To determine the developmental timing of axon subtype appearance in the mouse prostate.
To map the distribution of noradrenergic, cholinergic, and peptidergic axons during prostate development.
To investigate the innervation of prostate neuroendocrine cells by different axon subtypes.

Main Methods:

Immunohistochemical mapping of noradrenergic, cholinergic, and peptidergic axons in fetal, neonatal, and adult mouse prostates.
Development of a method for quantifying peri-prostatic axon density.
Analysis of axon distribution across the proximo-distal axis and association with neuroendocrine cells.

Main Results:

Noradrenergic, cholinergic, and peptidergic axons were first detected at embryonic day 14.5.
Noradrenergic and cholinergic axon densities were uniform across the adult prostate's proximo-distal axis.
Peptidergic axons showed higher density in proximal regions, and both peptidergic and cholinergic axons innervated neuroendocrine cells.

Conclusions:

Established the developmental timeline and spatial organization of major axon subtypes in the mouse prostate.
Demonstrated differential innervation patterns of prostate neuroendocrine cells by distinct axon types.
Provided a framework for future studies on prostatic axon development and disease-related changes.