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Comparison of Surgisis, Vypro II and TiMesh in contaminated and clean field

J Filipović-Čugura1, Z Misir1, P Hrabač2

  • 1Department of Surgery, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10000, Zagreb, Croatia.

Hernia : the Journal of Hernias and Abdominal Wall Surgery
|April 13, 2019
PubMed
Abstract

Insights

Infection resistance of surgical meshes (Surgisis, Vypro II, TiMesh) was evaluated in a rat model. Surgisis showed increased inflammation and infection signs, offering no benefits over Vypro II and TiMesh when contaminated.

Area of Science:

  • Biomaterials science
  • Surgical innovation
  • Infection control in surgery

Background:

  • Surgical mesh materials are crucial for hernia repair and tissue reinforcement.
  • Understanding mesh properties, including infection resistance and host response, is vital for patient outcomes.
  • Different mesh types, such as biological, composite, and non-resorbing, exhibit varied biocompatibility and performance.

Purpose of the Study:

  • To evaluate the histologic properties and infection resistance of three distinct surgical mesh materials: Surgisis, Vypro II, and TiMesh.
  • To compare the host response, including inflammation and foreign body reaction, to these meshes in both infectious and non-infectious settings.
  • To assess the efficacy of different mesh types in preventing infection under bacterial contamination.

Main Methods:

  • A rat model was used to implant three mesh types (Surgisis, Vypro II, TiMesh) in sublay and onlay positions.
  • Animals were divided into infectious and non-infectious groups, with samples collected at 7, 21, and 90 days post-implantation.
  • Histologic parameters evaluated included inflammation, vascularization, fibrosis, collagen formation, cell proliferation (Ki67), and foreign body granuloma formation.

Main Results:

  • Surgisis mesh induced more significant inflammation, cell proliferation, and less fibrosis compared to Vypro II and TiMesh.
  • In the presence of infection, the Surgisis group exhibited a higher incidence of local infection signs.
  • No significant difference in infection resistance was observed between Surgisis, Vypro II, and TiMesh when bacterial contamination was present.

Conclusions:

  • Surgisis mesh demonstrated a more pronounced inflammatory response and increased susceptibility to infection compared to Vypro II and TiMesh.
  • When bacterial contamination is a concern, Surgisis mesh offers no discernible advantage over Vypro II and TiMesh.
  • The choice of mesh material should consider its performance in infectious conditions to optimize surgical outcomes.
Keywords:
HerniaInfectionRat modelSurgisisTiMeshVypro II

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