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Updated: Jan 26, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
Multimodal imaging including optical coherence tomography angiography in patients with type B Niemann-Pick disease
Selim Bolukbasi1, Cezmi Dogan2, Ertugrul Kiykim3
1Department of Ophthalmology, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. selimbolukbasi@hotmail.com.
Purpose:
To evaluate accumulation patterns of deposits in retinal layers of type B Niemann-Pick patients by multimodal imaging.
Methods:
Seven patients with type B Niemann-Pick disease were included in this study. All participants underwent a complete ophthalmologic evaluation, high-resolution digital colour imaging, spectral-domain optical coherence tomography, blue light fundus autofluorescence and optical coherence tomography angiography (OCTA).
Results:
We demonstrated different accumulation patterns in the retinal ganglion cell layer, the retinal nerve fibre layer and the subfoveolar region by multimodal imaging. Local retinal capillary nonflow areas in the superficial plexus, increased vascular tortuosity and deformed foveal avascular areas were shown in OCTA scans.
Conclusion:
Multimodal imaging including OCTA is a useful technique for the identification of different types of accumulation patterns, diagnosis and follow-up of type B Niemann-Pick patients.
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