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Updated: Jan 26, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
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Published on: June 2, 2015

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Evaluation of pediatric glioma outcomes using intraoperative MRI: a multicenter cohort study

Michael Karsy1, S Hassan Akbari2, David Limbrick2

  • 1Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.

Journal of Neuro-Oncology
|April 13, 2019
PubMed
Abstract

Insights

Intraoperative MRI (iMRI) aided additional tumor resection in pediatric glioma patients, but its impact on extent of resection (EOR) and outcomes requires further validation due to varied use. Continued iMRI refinement may improve results.

Area of Science:

  • Neuro-oncology
  • Pediatric Neurosurgery
  • Medical Imaging

Background:

  • Intraoperative MRI (iMRI) may enhance glioma resection and patient survival but lacks validation in pediatric cases.
  • Current evidence on iMRI's benefits in pediatric glioma treatment is limited.

Purpose of the Study:

  • To evaluate the accuracy of iMRI in detecting residual pediatric glioma.
  • To determine iMRI's influence on surgical decisions, complication rates, and patient outcomes.

Main Methods:

  • Retrospective analysis of a multicenter database.
  • Inclusion of pediatric patients (≤18 years) with pathologically confirmed gliomas undergoing iMRI-assisted resection.

Main Results:

  • 314 pediatric patients with gliomas were analyzed (mean age 9.7 years).
  • iMRI guided additional resection in 46.8% of cases with residual tumor.
  • Pathological analysis confirmed tumor in 87.9% of specimens taken after iMRI.
  • Gross total resection was achieved in 55.7% of patients, though EOR was unknown in 24.6%.

Conclusions:

  • iMRI facilitated further tumor resection in a significant number of pediatric glioma cases.
  • Variability in iMRI application hinders definitive conclusions on its impact on EOR and outcomes.
  • Further development of iMRI techniques is recommended to optimize outcomes for pediatric glioma patients.
Keywords:
Extent of resectionGliomaIntraoperative MRIOutcomePediatricWHO gradeWorld Health of OrganizationiMRI

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