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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Neural Regulation01:37

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
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The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
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The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Related Experiment Video

Updated: Jan 26, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Proteomics in Neural Crest Cell Research.

Peter McCarthy1, Quenten Schwarz2

  • 1Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|April 13, 2019
PubMed
Summary
This summary is machine-generated.

Investigating the neural crest cell proteome is now feasible due to advanced proteomics techniques. New protocols enable deep analysis of protein profiles and modifications from minimal cell samples.

Keywords:
Neural crestProteomeProteomicsSILAC

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Area of Science:

  • Developmental Biology
  • Proteomics
  • Cell Biology

Background:

  • Investigating the neural crest cell proteome is challenging due to limited starting material and protein complexity.
  • Previous research has focused more on transcriptomics than proteomics for neural crest cells.
  • Limited proteomic data hinders a comprehensive understanding of neural crest cell biology.

Purpose of the Study:

  • To present novel quantitative proteomics protocols for neural crest cell analysis.
  • To enable deep profiling of the whole proteome and posttranslational modifications.
  • To facilitate ultrasensitive proteomic profiling from very small protein amounts.

Main Methods:

  • Development of a quantitative proteomics protocol for comprehensive analysis.
  • Establishment of a separate protocol for ultrasensitive proteomic profiling.
  • Utilizing recent advances in instrument sensitivity and sample preparation.

Main Results:

  • The study presents protocols for deep proteome and posttranslational modification analysis.
  • A protocol for ultrasensitive profiling from submicrogram protein amounts is detailed.
  • These methods overcome previous limitations in neural crest cell proteomics.

Conclusions:

  • Advanced proteomics techniques are now viable for neural crest cell research.
  • The presented protocols facilitate a deeper understanding of neural crest cell biology.
  • These methods open new avenues for studying neural crest cell development and function.