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T cell and dendritic cell interactions in lymphoid organs: More than just being in the right place at the right time

Milas Ugur1, Scott N Mueller1,2

  • 1Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

Immunological Reviews
|April 13, 2019
PubMed

The initiation of T lymphocyte responses within secondary lymphoid organs involves interactions with different subsets of dendritic cells (DCs). Recent studies have revealed the complexity of microanatomical organization within lymphoid organs. Exactly how T cells and DCs locate each other and the type of cellular interactions required for optimal priming of effector and memory T cell responses are beginning to be unraveled. Here we review advances in our understanding of how T cell priming is choreographed during infections, highlight the importance of cell positioning in this process and discuss how a spectrum of cellular interactions shapes T cell activation and differentiation.

Keywords:
T lymphocytesantigen presentationcell migrationdendritic cellsintravital imagingsecondary lymphoid organs

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