A Simple Non-Invasive Approach toward Efficient Transdermal Drug Delivery Based on Biodegradable Particulate System

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Dermatology

Background:

• Transdermal drug delivery via skin appendages offers localized and systemic benefits with reduced toxicity.
• Clinical application of effective transdermal methods remains a challenge.
• Novel carrier systems are needed for efficient drug transport through the skin.

Purpose of the Study:

• To develop and evaluate biodegradable calcium carbonate (CaCO3) particles for transdermal transport of bioactive substances.
• To investigate the penetration and release characteristics of CaCO3 carriers within hair follicles.
• To assess the systemic absorption and degradation profile of the proposed delivery system.

Main Methods:

• Fabrication of submicron porous CaCO3 particles.
• Topical application in rats followed by therapeutic ultrasound treatment.
• In vivo monitoring of particle penetration, follicle filling, and degradation.
• Tracking of a fluorescent marker for release and systemic absorption assessment.

Main Results:

• CaCO3 particles demonstrated deep skin penetration and filled hair follicles effectively.
• Efficient transport of a fluorescent marker to the hair follicle bulb was achieved.
• Particles underwent dissolution/recrystallization, with complete resorption within 12 days.
• Systemic absorption of the marker was confirmed via urinary excretion profiles.

Conclusions:

• Biodegradable CaCO3 particles serve as effective intrafollicular depots for prolonged drug release.
• The system shows promise for regenerative medicine, immunomodulation, and treating skin disorders.
• This transdermal delivery approach offers potential beyond traditional dermatology.