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Targeted therapies in urothelial bladder cancer: a disappointing past preceding a bright future?

Joya-Rita Hindy1, Tarek Souaid1, Hampig Raphael Kourie1,2

  • 1Medical Genetics Unit, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Future Oncology (London, England)
|April 13, 2019
PubMed

Insights

Targeted therapies show promise for advanced bladder cancer (BC) but lack approval. This review covers pivotal trials, ongoing studies, and immunotherapy combinations for BC treatment.

Area of Science:

  • Uro-oncology
  • Cancer Therapeutics
  • Clinical Trials

Background:

  • Bladder cancer (BC) is a prevalent urinary tract malignancy.
  • Targeted therapies have been investigated for advanced BC since the 2000s.
  • Despite extensive research, no targeted therapy is currently approved for BC.

Purpose of the Study:

  • To review pivotal clinical trials of targeted therapies in advanced bladder cancer.
  • To summarize ongoing trials evaluating targeted therapies based on specific biomarkers.
  • To discuss approved immunotherapies and their potential combination with targeted agents for BC.

Main Methods:

  • Literature review of clinical trials in advanced bladder cancer.
  • Analysis of targeted therapy efficacy based on biomarkers: FGFR3, EGFR, HER2, VEGF, and PI3K/AKT/mTOR.
  • Summary of ongoing clinical trials and approved immunotherapies.

Main Results:

  • Numerous trials have evaluated targeted therapies in advanced BC with varying biomarker targets.
  • No targeted therapy has yet received regulatory approval for bladder cancer treatment.
  • Several immunotherapies are approved, with ongoing research into combinations with targeted agents.

Conclusions:

  • Targeted therapy development for bladder cancer has faced challenges, with no approvals to date.
  • Ongoing trials and the exploration of immunotherapy combinations offer future therapeutic avenues.
  • Biomarker-driven approaches remain critical for advancing bladder cancer treatment strategies.
Keywords:
bladder cancerimmunotherapytargeted therapy

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