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Updated: Jan 26, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Serum biomarkers in the diagnosis of periprosthetic joint infection: consolidated evidence and recent developments
G Vicenti1, D Bizzoca, V Nappi
1Department of Basic Medical Sciences, Neuroscience and Sense Organs. Orthopaedic & Trauma Unit, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale "Policlinico", Bari, Italy. dott.gvicenti@gmail.com.
Abstract:
Periprosthetic Joint Infection (PJI) represents one of the leading causes of revision prosthetic surgery, accounting for 25% of failed Total Knee Replacement (TKR) and 15% of failed Total Hip Replacement (THR). The search for a biomarker that, together with clinical and radiological findings, could improve the management of such a kind of patients is currently a big challenge for orthopaedic surgeons. This review aims (1) to assess the accuracy and the limitations of the traditional (Serum Erythrocytes Sedimentation Rate, C-reactive Protein, Procalcitonin, Interleukin 6, Tumor Necrosis Factor alpha), (2) and to analyse the emerging serum biomarkers (Presepsin, Toll-like Receptor 2, soluble urokinase-type Plasminogen Activator Receptor, Chemokine Ligand 2 and Osteopontin) in the diagnosis of PJI. A special attention will be given to the emerging serum biomarkers, that could play an important role as first-line investigations, in the screening of PJI in a close future.
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