Bacterial interaction with host autophagy
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Updated: Jan 26, 2026

Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions
Published on: September 9, 2014
Yao-Wen Wu1,2,3, Fu Li1,2,3
1a Department of Chemistry, Umeå Centre for Microbial Research , Umeå University , Umeå , Sweden.
Abstract:
Autophagy is a conserved and fundamental cellular process mainly to recycle or eliminate dysfunctional cellular organelles or proteins. As a response to cellular stress, autophagy is used as a defense mechanism to combat the infection with pathogenic bacteria. However, many intracellular bacteria have developed diverse mechanisms to evade recognition, to manipulate the autophagic pathway, and to hijack the autophagosomal compartment for replication. In this review, we discuss recent understandings on how bacteria interact with host autophagy.
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