Related Experiment Videos
[A new test for evaluating the von Willebrand factor: collagen-induced agglutination of fixed thrombocytes]
In primary hemostasis von Willebrand factor (vWf) promotes the adhesion of platelets to subendothelial structures of the damaged blood vessel. A new test is described which measures the collagen binding affinity of vWf. Activities of vWf in plasmas of 51 patients were measured with either collagen (ColCof) or ristocetin (RCof). Regression-analysis showed a good correlation of both activities (r = 0.924). In a second group of 21 patients with a variant of von Willebrand's disease, ColCof activity was generally higher than RCof activity.
In primary hemostasis von Willebrand factor (vWf) promotes the adhesion of platelets to subendothelial structures of the damaged blood vessel. A new test is described which measures the collagen binding affinity of vWf. Activities of vWf in plasmas of 51 patients were measured with either collagen (ColCof) or ristocetin (RCof). Regression-analysis showed a good correlation of both activities (r = 0.924). In a second group of 21 patients with a variant of von Willebrand's disease, ColCof activity was generally higher than RCof activity.