Related Experiment Video

Updated: Jan 26, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

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Survival After Myectomy for Obstructive Hypertrophic Cardiomyopathy: What Causes Late Mortality?

Anita Nguyen1, Hartzell V Schaff1, Rick A Nishimura2

  • 1Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota.

The Annals of Thoracic Surgery
|April 13, 2019
PubMed

Insights

Survival after septal myectomy for obstructive hypertrophic cardiomyopathy is excellent. Most late deaths in these patients are unrelated to hypertrophic cardiomyopathy itself.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Genetics

Background:

  • Obstructive hypertrophic cardiomyopathy (oHCM) is a significant cardiac condition.
  • Septal myectomy is a surgical intervention for oHCM.
  • Long-term survival post-myectomy is crucial to evaluate.

Purpose of the Study:

  • To investigate the causes of late mortality in a large cohort of patients who underwent septal myectomy for oHCM.
  • To assess the long-term survival rates and causes of death after surgical treatment for oHCM.

Main Methods:

  • A retrospective review of 2,956 patients who underwent surgery for oHCM between 1961 and 2017.
  • Verification of vital status and causes of mortality using LexisNexis Accurint and the National Death Index.
  • Analysis of demographic data, genetic testing results, and mortality outcomes.

Main Results:

  • 1-year, 10-year, and 20-year survival rates were 98%, 85%, and 52%, respectively.
  • Mortality occurred in 16% of patients; hypertrophic cardiomyopathy was the primary cause in less than 20% of these deaths.
  • Non-cardiac causes accounted for 44% of deaths; other cardiac causes included coronary artery disease and stroke.

Conclusions:

  • Septal myectomy provides excellent long-term survival for patients with oHCM.
  • The majority of late deaths are not directly attributable to hypertrophic cardiomyopathy.
  • Genetic status did not significantly impact overall mortality in this cohort.
Abstract

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