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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
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Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
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Engineered Polymeric Hydrogels for 3D Tissue Models.

Sujin Park1, Kyung Min Park2

  • 1Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Korea. sujin.park@inu.ac.kr.

Polymers
|April 14, 2019
PubMed
Summary
This summary is machine-generated.

Polymeric hydrogels offer versatile solutions for tissue engineering and drug delivery. Advanced hydrogel technologies create sophisticated 3D tissue models, mimicking native tissues for research and therapeutic applications.

Keywords:
artificial extracellular matricesbasic cell biologydrug screeningengineered tissue modelspolymeric hydrogelstissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Polymeric biomaterials are crucial in biomedical applications due to biocompatibility and tunability.
  • Polymeric hydrogels serve as therapeutic implants, drug delivery vehicles, and artificial cellular microenvironments.
  • Hydrogels mimic native extracellular matrices, enabling advanced 3D tissue model development.

Purpose of the Study:

  • To review the use of polymeric hydrogels in creating engineered tissue constructs.
  • To highlight emerging technologies for advanced tissue models.
  • To discuss recapitulating complex native tissues in vivo.

Main Methods:

  • Review of current literature on polymeric hydrogels in tissue engineering.
  • Focus on advanced fabrication techniques for hydrogel-based tissue models.
  • Analysis of hydrogel properties enabling recapitulation of native tissue complexity.

Main Results:

  • Polymeric hydrogels are instrumental in developing sophisticated 3D tissue models.
  • Engineered hydrogels provide a platform for tissue regeneration and drug discovery.
  • Emerging technologies enable precise recapitulation of in vivo tissue characteristics.

Conclusions:

  • Polymeric hydrogels are key components in advanced tissue engineering.
  • Hydrogel-based tissue models offer promising alternatives for drug testing and disease modeling.
  • Future research focuses on enhancing the biomimicry of engineered tissues.