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Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules
Yolanda Alvarado Pérez1, Claudia Muro Urista2, Javier Illescas Martínez3
1Departamento de Ingeniería Química e Investigación, Instituto Tecnológico de Toluca, Apartado Postal 890, 52149 Metepec, MEX, Mexico. yoal68@hotmail.com.
Polymers
|April 14, 2019
Summary
Functionalized polymers enhance oral bioavailability for sensitive molecules by protecting them from degradation and improving absorption. This review covers their applications and future trends in medicine.
Area of Science:
- Biomaterials Science
- Pharmaceutical Sciences
- Drug Delivery
Background:
- Sensitive biomolecules often degrade in the gastrointestinal tract (GIT), limiting oral administration.
- Physicochemical instability, inactivation, poor solubility, and permeability are key challenges.
- Enhancing oral bioavailability of these molecules is a critical research area in medicine.
Purpose of the Study:
- To review the role of functionalized polymers in improving oral bioavailability of sensitive molecules.
- To summarize the current application status of these polymers in medicine for various diseases.
- To discuss future trends and formulation goals for oral delivery.
Main Methods:
- Literature review focusing on functionalized polymers for oral drug delivery.
- Analysis of strategies to protect biomolecules from GIT degradation.
- Evaluation of polymers' impact on absorption, permeability, and stability.
Main Results:
- Functionalized polymers offer protection against enzymatic degradation in the stomach.
- These polymers improve drug absorption, permeability, and stability in the GIT.
- Advances in polymer properties enable tailored drug release profiles.
Conclusions:
- Functionalized polymers represent a promising strategy for effective oral delivery of sensitive molecules.
- These materials are advancing from basic research to clinical development for diverse therapeutic applications.
- Further research into functionalized polymers will unlock new formulation possibilities for oral administration.
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