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New Developments in Imaging Cell-Based Therapy.

Olivier Martinez1, Jane Sosabowski2, John Maher3,4,5

  • 1ImmunoEngineering Group, School of Cancer and Pharmaceutical Sciences, King's Health Partners Integrated Cancer Centre, Guy's Hospital, King's College London, London, United Kingdom.

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Summary
This summary is machine-generated.

Cancer immunotherapy, particularly cell-based therapies, is advancing rapidly. Recent innovations in in vivo tracking using novel tracers and reporter genes are crucial for optimizing treatment efficacy and managing toxicity in oncology.

Keywords:
cell therapymolecular imagingoncologyradioimmunoimagingradiotracers

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Area of Science:

  • Oncology
  • Immunology
  • Medical Imaging

Background:

  • Cancer immunotherapy, especially cell-based therapies, is a cornerstone of hematologic oncology.
  • These therapies are expanding into solid tumors and nonmalignant conditions.
  • In vivo tracking of cellular therapies is essential for optimizing efficacy and managing toxicity.

Purpose of the Study:

  • To review key developments in in vivo tracking technologies for cell-based therapies over the past five years.
  • To highlight advancements in tracers and reporter genes for longitudinal imaging of cellular therapies.

Main Methods:

  • Review of recent literature on cell-based therapies and in vivo tracking.
  • Focus on novel tracers for passive cell labeling.
  • Emphasis on reporter gene strategies for longitudinal imaging.

Main Results:

  • Introduction of novel tracers for passive labeling of cell products.
  • Advances in reporter gene technology for longitudinal in vivo imaging.
  • Growing importance of in vivo tracking for therapeutic optimization.

Conclusions:

  • In vivo tracking technologies are rapidly evolving and crucial for advancing cell-based cancer immunotherapies.
  • These advancements will aid in optimizing treatment strategies and patient management.
  • The scope of cell-based therapies and their tracking is broadening beyond hematologic oncology.