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Updated: Jan 26, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
[Ketamine in the therapy of chronic pain and depression]
Wolfgang Jaksch1,2, Rudolf Likar3,4,5, Martin Aigner3,6
1Österreichische Schmerzgesellschaft, Wien, Österreich. wolfgang.jaksch@chello.at.
Abstract:
Although ketamine has been known and clinically applied for a long time, questions still arise around the many possible indications in which the anesthetic and analgesic substance could be used. In particular, these questions relate to new indications in which ketamine is used in low subanesthetic doses.The mechanism of action at the NMDA receptor clearly distinguishes ketamine from all other analgesics. Possible applications include the prevention of chronic postoperative pain as well as the treatment of neuropathic pain. With the treatment of refractory depression completely new therapeutic areas for ketamine could be established.
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