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Next Generation Proteomics for Clinical Biomarker Detection Using SWATH-MS

Qifeng Lin1, Hwee Tong Tan1, Maxey C M Chung2

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Methods in Molecular Biology (Clifton, N.J.)
|April 14, 2019
PubMed
Summary

Sequential windowed acquisition of all theoretical fragment ion spectra (SWATH-MS) identified laminin β-1 (LAMB1) as a novel biomarker for colorectal cancer. LAMB1 shows improved diagnostic performance over carcinoembryonic antigen (CEA) in patient serum samples.

Keywords:
BiomarkerColorectal cancerData-independent acquisitionSWATH-MSSecretome

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