Effects of ethylhydroxydiphosphonate (EHDP) on heterotopic ossification

The effect of EHDP medication was studied in 25 patients in whom heterotopic ossifications around the hip (19 cases) and elsewhere were resected. EHDP seemed to have a favorable effect on prevention of reossification and on function, particularly when ectopic ossifications were resected after total hip replacement. In all the patients, EHDP administration postponed mineralization of osteoid.