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Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
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Fetal anogenital distance using ultrasound
Ezra Aydin1, Rosemary Holt1, Daren Chaplin2
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Prenatal Diagnosis
|April 14, 2019
Summary
Fetal anogenital distance (AGD) can be noninvasively measured via ultrasound, showing significant sex differences and population variations between UK and Israeli samples. This confirms AGD
Area of Science:
- Prenatal diagnostics
- Fetal development
- Reproductive endocrinology
Background:
- Anogenital distance (AGD) is a recognized marker of prenatal androgen exposure.
- Previous studies suggest AGD can be measured noninvasively in fetuses.
- Population-specific reference ranges for fetal AGD may be necessary.
Purpose of the Study:
- To confirm the feasibility of noninvasive fetal anogenital distance (AGD) measurement using ultrasound.
- To investigate sex-based differences in fetal AGD.
- To compare fetal AGD reference ranges between different populations.
Main Methods:
- Recruitment of 210 singleton pregnancies in the UK.
- 2D ultrasound measurements of AGD between 26-30 weeks gestation.
- Comparison of AGD data with an Israeli sample, controlling for gestational age.
Main Results:
- Significant sex differences in fetal AGD were observed (P < .0001).
- A correlation between estimated fetal weight and AGD was found in males only (P = .006).
- Significant differences in AGD were found between UK and Israeli populations for both sexes (P < .0001).
Conclusions:
- Fetal AGD measurement via ultrasound is feasible and reliable.
- Observed sex differences in AGD support the role of prenatal androgen exposure.
- Population-specific reference values for fetal AGD are recommended for accurate clinical assessment.
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