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Tacrolimus Therapy in Steroid-Refractory Ulcerative Colitis: A Review
Biyu Wu1, Jinglu Tong1, Zhihua Ran1
1Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Abstract:
Inflammatory bowel diseases are known for a chronic inflammatory process of the gastrointestinal tract and include Crohn's disease and ulcerative colitis (UC). Patients who are dependent on or resistant to corticosteroids account for about 20% of severe UC patients. Tacrolimus is a calcineurin inhibitor that has recently been used in the treatment of steroid-refractory ulcerative colitis. Tacrolimus has been demonstrated to have remarkable therapeutic efficacy in UC patients, without increased risk of severe adverse effects such as induction of remission and maintenance therapy. This article reviews the mechanism of action, pharmacogenetics, efficacy, and safety of tacrolimus for patients with steroid-refractory ulcerative colitis.
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