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Related Experiment Video

Updated: Jan 26, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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The need for dried plasma - a national issue.

Anthony E Pusateri1, Frank K Butler2, Stacy A Shackelford3

  • 1US Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, Texas.

Transfusion
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Summary

Early blood transfusions, including plasma and red blood cells (RBCs), significantly improve survival in severe trauma and hemorrhagic shock patients. A US-approved dried plasma product is urgently needed for prehospital use.

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Area of Science:

  • Emergency Medicine
  • Trauma Surgery
  • Blood Transfusion

Background:

  • Early transfusion of plasma or red blood cells (RBCs) is critical for improving survival in patients with severe trauma and hemorrhagic shock.
  • Prehospital transfusion is essential when transport times exceed 15-20 minutes, but logistic constraints limit its use.
  • Current US military needs and disaster preparedness highlight the demand for logistically supportable blood products.

Purpose of the Study:

  • To emphasize the urgent need for a US Food and Drug Administration (FDA)-approved dried plasma product.
  • To address the limitations of current prehospital blood product availability.
  • To highlight the national healthcare issue concerning remote civilian trauma and military requirements.

Main Methods:

  • This study is a review and analysis of current literature and military/civilian healthcare needs.
  • It examines the efficacy of early transfusion strategies.
  • It assesses the logistical challenges and requirements for prehospital blood products.

Main Results:

  • Early transfusion of plasma and RBCs demonstrably improves survival rates in severe trauma.
  • Logistic constraints severely restrict prehospital blood product administration.
  • A dried plasma product has been used internationally for over 20 years, but none is commercially available in the US.

Conclusions:

  • A US-approved dried plasma product is urgently required to address critical prehospital transfusion needs.
  • Availability of dried plasma would significantly benefit military operations, disaster response, and remote civilian trauma care.
  • Developing and approving dried plasma is a national healthcare priority.