Cardiopulmonary coupling analysis predicts early treatment response in depressed patients: A pilot study

This pilot study evaluated the effect of anti-depression treatment on sleep quality and symptoms of depression in patients with major depressive disorder, and identified cardiopulmonary coupling (CPC) indices for predicting early response. Forty-one Han Chinese patients with major depressive disorder were assessed for objective sleep quality before treatment (baseline) and at 2 weeks using CPC. Subjective sleep quality and depression levels were measured at baseline and 2 and 4 weeks after treatment, using the 24-item Hamilton Rating Scale for Depression (HAMD-24), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI). Objective and subjective sleep quality, and depression symptoms, improved after treatment. Significant correlations were found between CPC variables at baseline and depression symptom improvement after 2 weeks of treatment. Total sleep time at baseline significantly correlated with somnipathy score reduction at week 2. Total in-bed time at week 2 significantly correlated with reductions in anxiety/somatic symptoms and retardation score, and total HAMD-24 score at week 4. In binary logistic regression, the total in-bed time at baseline was significantly associated with treatment response. Our findings suggest that objective sleep quality measured by CPC analysis is useful for predicting treatment response to antidepressant treatment in patients with major depressive disorder.