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Updated: Jan 26, 2026
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
The rash that presents as target lesions
Ronni Wolf1, Jennifer L Parish2, Lawrence Charles Parish3
1The School of Medicine, Hebrew University, Jerusalem, Israel; Hadassah Medical Center, Jerusalem, Israel.
Abstract:
We have explored the rash that appears as target lesions, with the central and dominant diseases belonging to the Stevens-Johnson syndrome/toxic epidermal necrolysis group. After presenting the clinical patterns of an individual target lesion and classifying them into different types of lesions, the contribution has been organized with groups characterized by such specific findings according to the type of lesion: flat or raised, typical or atypical, presence or absence of fever, presence or absence of mucosal ulcerations, presence or absence of arthralgias, and/or internal organ involvement. Other specific features, such as histologic appearance, immunofluorescence findings, and laboratory changes, are considered. We provide clinicians with an algorithmic, systematic, and logical approach to diagnose the condition of the patients who present with targetoid lesions, and enable them to differentiate between those with serious systemic and life-threatening diseases from others with ordinary skin ailments.
Insights
This study classifies target lesions to help diagnose Stevens-Johnson syndrome/toxic epidermal necrolysis. It provides a diagnostic approach for clinicians to distinguish severe conditions from common skin ailments.
Area of Science:
- Dermatology
- Internal Medicine
Background:
- Target lesions are characteristic of severe mucocutaneous diseases.
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions presenting with targetoid rashes.
Purpose of the Study:
- To systematically classify target lesions.
- To develop a diagnostic algorithm for differentiating SJS/TEN from other conditions presenting with targetoid lesions.
Main Methods:
- Clinical pattern analysis of target lesions.
- Classification based on lesion morphology (flat/raised, typical/atypical).
- Correlation with clinical features (fever, mucosal ulcerations, arthralgias) and systemic involvement.
Main Results:
- Detailed categorization of target lesions is presented.
- Specific clinical and histological features are associated with SJS/TEN.
- An algorithmic approach aids in diagnosis.
Conclusions:
- A structured approach to evaluating target lesions is crucial for timely SJS/TEN diagnosis.
- Differentiating SJS/TEN from benign conditions requires careful assessment of specific clinical and pathological findings.
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