Infectious complications after kidney transplantation

Infectious complications are one of the leading causes of hospitalization and mortality in kidney transplant recipients. They are more frequent during the year following transplantation, and in the elderly. Community infections, such as pyelonephritis and pneumonia, are from far the most common infections. However, the field of opportunistic infections has been particularly moving as routine prophylaxis for cytomegalovirus and pneumocystosis have altered their patterns. Emergence of new infections, as BK nephritis, followed by chronic infections by Norovirus and E hepatitis, and increasing incidence of invasive fungal infections and mycobacterial infections have raised concerns. An increasing number of infections may be prevented by prophylaxis, but also by vaccines who should be encouraged, especially for influenza, pneumococcal diseases and zoster. Access to transplantation is now possible for human immunodeficiency virus infected patients, with good results. The field of infectious diseases is thus changing in kidney transplant recipients, due to high-risk recipients, new immunosuppressive drugs, and development of new diagnostic, therapeutic and preventive methods.