[M monoclonal macroglobulinemia induced in BALB/C mice. Effect on blood cholesterol and its significance]

BALB/C mice have been inoculated with a monoclonal IgM secreting hybridoma and have developed an hypocholesterolemia strongly dependent of the hypermacroglobulinemia M obtained (P less than 0.001). Cholesterolegram shows cholesterol is carried on the monoclonal IgM fraction. This result has been established in comparison with a lot of mice treated with the same no secreting hybridoma and a lot of untreated-mice, in these cases cholesterolemia is not modified. The whole aminoacids sequence of this IgM being nearly achieved, it is thinked of check the hypocholesterolemic activity of several parts of this immunoglobulin.