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Prenatal Bisphenol A exposure and early childhood neurodevelopment in Shandong, China

Rui Pan1, Caifeng Wang2, Rong Shi1

  • 1Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International Journal of Hygiene and Environmental Health
|April 15, 2019
PubMed

Insights

Prenatal exposure to Bisphenol A (BPA) may negatively impact infant neurodevelopment, particularly in girls. This study in China highlights potential risks at 12 and 24 months, emphasizing the need for further research.

Area of Science:

  • Environmental Health
  • Developmental Pediatrics
  • Toxicology

Background:

  • Epidemiological studies suggest prenatal Bisphenol A (BPA) exposure may affect neurodevelopment in older children.
  • Limited research exists on BPA's effects on neurodevelopment in younger children, especially in China.

Purpose of the Study:

  • To investigate the association between prenatal BPA exposure and neurodevelopment in infants at 12 and 24 months of age.
  • To assess these effects in a Chinese birth cohort.

Main Methods:

  • Urine BPA concentrations were measured in 506 pregnant women.
  • Infant neurodevelopment was assessed using Gesell Development Schedules at 12 and 24 months.
  • Linear regression and generalized linear models analyzed the association between BPA exposure and developmental quotient scores (DQs).

Main Results:

  • Maternal BPA concentrations were inversely associated with infant DQs at 12 months.
  • A 10-fold increase in BPA correlated with a 1.43-point decrease in adaptive DQs.
  • Adverse associations were observed in adaptive domains for both genders and social domains for girls at 12 months, and language domains for girls at 24 months.

Conclusions:

  • Prenatal BPA exposure may adversely impact childhood neurodevelopment in a Chinese population.
  • Effects were observed at 12 and 24 months, with notable impacts on girls' development.
  • Findings underscore the potential risks of BPA during critical developmental windows.
Abstract

Keywords:
Bisphenol AChildrenChinaNeurodevelopmentPrenatal

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