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HOX transcript antisense RNA (HOTAIR) in cancer

Xiaohan Qu1, Simon Alsager2, Ying Zhuo3

  • 1Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, China.

Cancer Letters
|April 15, 2019
PubMed

Insights

Long noncoding RNAs (lncRNAs) like HOTAIR are key cancer regulators. HOTAIR's elevated expression promotes cancer progression, metastasis, and poor prognosis, highlighting its diagnostic and therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as crucial regulators in cancer development.
  • The lncRNA HOX transcript antisense RNA (HOTAIR) is a significant oncogenic factor.
  • Elevated HOTAIR expression correlates with advanced cancer stages, metastasis, and unfavorable patient outcomes.

Purpose of the Study:

  • To review the diagnostic and therapeutic potential of HOTAIR in cancer.
  • To elucidate the molecular mechanisms behind HOTAIR dysregulation in cancer.
  • To discuss challenges and future directions for leveraging HOTAIR in patient care.

Main Methods:

  • Literature review of preclinical and clinical studies on HOTAIR in cancer.
  • Analysis of molecular interactions and functions of HOTAIR.
  • Discussion of current research on HOTAIR's role in cancer biology.

Main Results:

  • HOTAIR promotes cancer proliferation, invasion, survival, drug resistance, and metastasis.
  • HOTAIR interacts with various molecular partners to drive oncogenic processes.
  • Dysregulation of HOTAIR expression and function is a common feature across many cancer types.

Conclusions:

  • HOTAIR presents significant potential as a diagnostic biomarker and therapeutic target in oncology.
  • Understanding HOTAIR's molecular mechanisms is crucial for developing effective cancer treatments.
  • Further research is needed to overcome challenges and translate HOTAIR-based strategies into clinical practice.
Keywords:
EpigeneticsG-quadruplexPRC2R-loop

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