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Updated: Jan 26, 2026
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Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
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A Trained Pulmonologist Can Reliably Assess Endosonography-Derived Lymph Node Samples during Rapid On-Site Evaluation
Filippo Natali1, Alessandra Cancellieri2, Carmine Tinelli3
1Interventional Pulmonology Unit, Policlinico Sant'Orsola-Malpighi and Ospedale Maggiore, Bologna, Italy.
Respiration; International Review of Thoracic Diseases
|April 15, 2019
Summary
A trained pulmonologist can reliably assess endosonography-derived lymph node samples for adequacy and malignancy. This finding supports its use in settings lacking regular cytopathology support, improving diagnostic efficiency.
Area of Science:
- Pulmonology
- Cytopathology
- Oncology
Background:
- Rapid on-site evaluation (ROSE) is limited by time, resources, and reimbursement.
- Previous trials showed ROSE did not increase diagnostic yield or specimen adequacy.
Purpose of the Study:
- To determine if a pulmonologist can assess endosonography-derived lymph node samples after pathologist training.
- To evaluate the reliability of pulmonologist-led sample assessment.
Main Methods:
- Prospective, observational trial in three phases: training, test, and real-life.
- Pathologist trained a pulmonologist using archival cases.
- Pulmonologist assessed 50 archival and 200 real-life samples.
- Agreement assessed using kappa statistics.
Main Results:
- Overall agreement between pulmonologist and pathologist was 84% (test phase) and 89.7% (real-life phase).
- High agreement for inadequate samples (92.7%), reactive lymphadenopathies (90.3%), and malignancy (90.5%).
- Agreement for granulomatous samples was 73%.
Conclusions:
- Trained pulmonologists can reliably assess sample adequacy and malignancy from endosonography.
- This approach can be valuable in institutions without regular cytopathologist availability.
- Enhances diagnostic capabilities in resource-limited settings.
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