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Multiple flat-topped scaly violaceous papules.
Raghavendra L Girijala1, Domina Nyinawinyange, Palak K Parekh
1Texas A & M University College of Medicine, College Station, Texas. rgirijala@gmail.com.
Dermatology Online Journal
|April 16, 2019
Summary
Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder causing susceptibility to human papillomavirus (HPV). This case study details a patient
Area of Science:
- Dermatology
- Genetics
- Immunology
Background:
- Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis.
- It is characterized by susceptibility to beta-genus human papillomavirus (HPV) infection.
- Mutations in TMC6/EVER1 and TMC8/EVER2 disrupt endoplasmic reticulum function and immune pathways, impairing keratinocyte defense against HPV.
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