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Updated: Jan 26, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Left ventricular wall motion abnormality is associated with cryptogenic stroke.

Jeong-Yoon Choi1, Jaehyung Cha2, Jin-Man Jung3

  • 1Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea.

International Journal of Stroke : Official Journal of the International Stroke Society
|April 16, 2019
PubMed
Summary

Left ventricular wall motion abnormality (LVWMA) is a significant risk factor for cryptogenic stroke, comparable to cardioembolic stroke. Unexplained LVWMA may be an independent predictor of cryptogenic stroke.

Keywords:
Left ventricular wall motion abnormalitycardioembolismcryptogenic stroke

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Area of Science:

  • Cardiology
  • Neurology
  • Stroke Research

Background:

  • Left ventricular wall motion abnormality (LVWMA) without known cardiac risk factors presents an uncertain stroke risk.
  • Understanding the link between LVWMA and stroke etiology is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between LVWMA and cryptogenic stroke.
  • To compare this association with other stroke subtypes.

Main Methods:

  • Retrospective observational study of 4316 acute ischemic stroke patients.
  • Analysis of LVWMA prevalence and its association with stroke subtypes using logistic and multinomial regression.

Main Results:

  • LVWMA was present in 10.0% of patients.
  • LVWMA was independently associated with cryptogenic stroke (OR=1.627-4.950 across subtypes).
  • The association of LVWMA with cryptogenic stroke was comparable to cardioembolic stroke and stronger than non-cardioembolic stroke.

Conclusions:

  • LVWMA unrelated to known cardiac risk factors may serve as an independent risk factor for cryptogenic stroke.
  • Findings suggest LVWMA is a significant predictor, particularly for cryptogenic and cardioembolic strokes.