Related Experiment Video

Updated: Jan 26, 2026

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
08:00

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

Published on: June 15, 2015

14.4K

Update on catheter ablation research from The 2019 European Heart Rhythm Association Congress

Pasquale Santangeli1, Kenneth A Ellenbogen2

  • 1Division of Cardiovascular, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of Cardiovascular Electrophysiology
|April 16, 2019
PubMed

Insights

Catheter ablation for atrial fibrillation (AF) and ventricular tachycardia (VT) shows high efficacy, outperforming drug therapy. Edoxaban is a safe alternative for anticoagulation during AF ablation procedures.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Technology

Background:

  • The 2019 European Heart Rhythm Association (EHRA) scientific meetings highlighted key advancements in catheter ablation for atrial fibrillation (AF) and ventricular tachycardia (VT).
  • Late-breaking trials presented significant findings impacting clinical practice for arrhythmia management.

Framework:

  • Three multicenter randomized controlled trials confirmed the equal and high efficacy of radiofrequency and cryoballoon ablation for AF, demonstrating superiority over antiarrhythmic drugs.
  • A large randomized study established Edoxaban as a safe and effective periprocedural anticoagulant for AF ablation, comparable to warfarin.

Implementation:

  • Mechanistic studies utilized small electrode mapping to explore electrophysiologic features of concealed substrates in myocardial infarction (MI).
  • Research also investigated the temporal evolution of arrhythmogenic substrates post-MI.
  • Observational studies support integrating cardiac imaging (CMR, CT) for guiding VT substrate ablation.

Implications:

  • These findings reinforce catheter ablation as a primary treatment for AF and VT, offering improved outcomes and reduced hospitalizations.
  • Edoxaban provides a valuable anticoagulation option for AF ablation patients.
  • Advanced imaging integration promises more precise and effective VT ablation strategies.

More Related Videos

Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation11:03

Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation

Published on: February 26, 2013

20.5K
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

15.3K

Related Concept Videos

Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
2.7K
SI Units: 2019 Redefinition01:13

SI Units: 2019 Redefinition

Measurement is an indispensable part of analytical chemistry. The result of measurement helps quantify a substance's physical property and compare it with the physical property of another substance. Each measurement comprises two components - a number indicating the magnitude and a unit of measurement as a standard for comparison. Further, the same quantity can be measured using different units of measurement, which leads to differences in magnitude.
A standard set of units has been defined...
3.4K
Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.4K
ECG Interpretation of Rhythms01:24

ECG Interpretation of Rhythms

An electrocardiogram (ECG)graphically represents the heart's electrical activity on ECG paper or a monitor.
Components of the Electrocardiogram
The primary components of a normal ECG waveform in Normal sinus rhythm(NSR) include the P wave, PR interval, QRS complex, ST segment, T wave, and occasionally a U wave.
ECG waveforms are divided by vertical and horizontal lines at standard intervals.
The horizontal axis measures time and rate, and the vertical axis measures amplitude or voltage....
13.5K
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.9K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K