Aggregation-Induced Emission-Based Sensing Platform for Selective Detection of Zn²⁺ : Experimental and Theoretical...

Fluorescent chemosensors with aggregation induced emission enhancement (AIEE) emerge as promising tools in the field of sensing materials. Herein, we report the design, synthesis and applicability of a Schiff base chemosensor 1-(benzo[1,3]dioxol-4-ylmethylene-hydrazonomethyl)-naphthalen-2-ol (Hbdhn) of AIE characteristics that exhibits highly effective and selective response towards Zn²⁺ . The sensing effect of Hbdhn was evaluated by means of absorption/emission spectra and corresponding underlying photophysical mechanisms were proposed based on extensive quantum-chemical (TD)DFT calculations. The aggregated states in different DMSO/H₂ O ratios and in a presence of Zn²⁺ were examined by fluorescence lifetime measurements, dynamic light scattering and scanning electron microscopy studies. The bioimaging abilities of Hbdhn were evaluated for Zn²⁺ in HepG2 cancer cells. The results demonstrate instant, stable in time and reproducible, colorimetric turn-on response with superb selectivity and sensitivity of Hbdhn towards Zn²⁺ , based on chelation enhanced fluorescence mechanism. AIEE improves further Hbdhn properties, leading to strong, long-lived fluorescence, with appearance of rod-like particles, in 90 % of water in DMSO and only 10 % of water in DMSO in the presence of Zn²⁺ . All these features combined with successful biomaging studies make Hbdhn one of the most promising candidate for practical applications among recently proposed related systems.