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IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
Iridium-Catalyzed Asymmetric Borylation of Unactivated Methylene C(sp3)-H Bonds
Ronald L Reyes1,2, Tomohiro Iwai1, Satoshi Maeda1,2
1Department of Chemistry, Faculty of Science , Hokkaido University , Sapporo 060-0810 , Japan.
Abstract:
Herein, we show the highly enantioselective borylation of unactivated methylene C(sp3)-H bonds in 2-alkylpyridines and 2-alkyl-1,3-azole derivatives using an iridium-BINOL-based chiral monophosphite catalyst system. Quantum chemical calculations using the artificial force induced reaction (AFIR) method suggested that a monophosphite-Ir-tris(boryl) complex generates a narrow chiral reaction pocket where the differentiation of the enantiotopic methylene C-H bonds is accomplished through an assembly of multiple noncovalent interactions.
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