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Platelet function in preeclampsia - a systematic review and meta-analysis
Carina Jakobsen1, Julie Brogaard Larsen1, Jens Fuglsang2,3
1a Centre for Haemophilia and Thrombosis, Department of Clinical Biochemistry , Aarhus University Hospital , Aarhus , Denmark.
Platelets
|April 16, 2019
Summary
Preeclampsia is a serious pregnancy complication. This review found mean platelet volume (MPV) significantly increased in preeclampsia patients, suggesting its potential as a key biomarker.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Biomarker Research
Background:
- Preeclampsia is a significant pregnancy complication with potential platelet involvement.
- Platelet function analyses are explored as sensitive biomarkers for preeclampsia detection.
Purpose of the Study:
- To systematically review and summarize literature on platelet function markers in preeclampsia.
- To evaluate the potential of platelet markers as diagnostic or predictive tools for preeclampsia.
Main Methods:
- Systematic literature review following PRISMA guidelines, registered in PROSPERO.
- Searched PubMed and Embase for studies on platelet activation, aggregation, and adhesion markers.
- Conducted meta-analysis on mean difference of markers between preeclampsia and control groups.
Main Results:
- Some platelet activation markers, notably p-selectin and mean platelet volume (MPV), were significantly elevated in preeclampsia.
- Meta-analysis confirmed significantly higher MPV in women with preeclampsia compared to controls.
- No significant differences were observed in platelet aggregation; platelet adhesion was not investigated.
Conclusions:
- Mean platelet volume (MPV) shows promise as a biomarker for assessing platelet function in preeclampsia.
- Further research is needed to explore the role of platelet activation markers in predicting preeclampsia.
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