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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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Transfer RNA Synthesis02:36

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
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Related Experiment Video

Updated: Jan 26, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Long Non-Coding RNA and Breast Cancer.

Tianzhu Zhang1,2, Hui Hu1, Ge Yan1,2

  • 11 Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Technology in Cancer Research & Treatment
|April 16, 2019
PubMed
Summary

Long non-coding RNAs are crucial in breast cancer development and progression. This review highlights their regulatory roles in cell proliferation, invasion, metastasis, and apoptosis, offering insights into this complex disease.

Keywords:
apoptosisbreast cancercell proliferationinvasionlong non-coding RNAmetastasismolecular mechanisms

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a common, heterogeneous disease posing significant public health challenges.
  • Long non-coding RNAs (lncRNAs) are gaining attention due to next-generation sequencing advancements.
  • Aberrant expression of lncRNAs is observed in various cancers, including breast cancer.

Purpose of the Study:

  • To summarize recent literature on the role of lncRNAs in breast cancer.
  • To focus on the molecular mechanisms of regulatory lncRNAs in breast cancer progression.
  • To elucidate the involvement of lncRNAs in cell proliferation, invasion, metastasis, and apoptosis.

Main Methods:

  • Literature review of recent studies on lncRNAs and breast cancer.
  • Analysis of molecular roles and mechanisms of specific lncRNAs.
  • Focus on lncRNA regulation of key cancer hallmarks.

Main Results:

  • lncRNAs play significant, multifaceted roles in breast cancer development.
  • Specific lncRNAs are abnormally expressed and contribute to tumor progression.
  • lncRNAs regulate critical processes including cell proliferation, invasion, metastasis, and apoptosis.

Conclusions:

  • lncRNAs are important regulators in breast cancer, influencing multiple stages of tumorigenesis.
  • Understanding lncRNA functions is key to unraveling breast cancer complexity.
  • Targeting lncRNAs may offer novel therapeutic strategies for breast cancer.