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Updated: Jan 26, 2026
10:21
Microfluidic Applications for Disposable Diagnostics
Published on: February 3, 2008
9.3K
Cell-free DNA diagnostics: current and emerging applications in oncology
Penn Muluhngwi1, Roland Valdes1, Rafael Fernandez-Botran1
1Department of Pathology & Laboratory Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Pharmacogenomics
|April 16, 2019
Summary
Liquid biopsy, a noninvasive method, offers a less risky and more frequent alternative to tissue biopsy for disease monitoring. Circulating tumor DNA analysis shows high concordance with primary tumors, supporting its diagnostic potential.
Area of Science:
- Oncology
- Molecular Diagnostics
- Biomarkers
Background:
- Liquid biopsy provides a noninvasive method for dynamic disease monitoring.
- It presents advantages over tissue biopsy, including reduced risk, frequent sampling, lower costs, and unbiased sampling.
- High concordance exists between circulating tumor DNA (ctDNA) mutations and primary tumor mutations.
Purpose of the Study:
- To discuss the progress of liquid biopsy adoption as a diagnostic tool.
- To identify and address remaining knowledge gaps for broader implementation.
Main Methods:
- Review of current literature and clinical data on liquid biopsy.
- Analysis of concordance studies between ctDNA and tissue biopsies.
- Discussion of remote sampling feasibility in diagnostics.
Main Results:
- Liquid biopsy demonstrates significant potential as a diagnostic tool.
- High concordance rates support the use of ctDNA for disease monitoring.
- Remote sampling is a viable option for clinical diagnostics.
Conclusions:
- Liquid biopsy is advancing as a valuable noninvasive diagnostic and monitoring tool.
- Further research is needed to address knowledge gaps for widespread clinical adoption.
- The potential for frequent, low-risk sampling enhances patient care and disease management.
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