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Validation of Three-dimensional Electronic Portal Imaging Device-based PerFRACTION™ Software for Patient-Specific
A Aziz Sait1, Jason Figueredo2, Glenn W Jones3
1Department of Radiation Oncology, The Cancer Centre Eastern Caribbean, St. John's, Antigua.
Journal of Medical Physics
|April 16, 2019
Summary
This study validates PerFRACTION™ software for 3D dosimetry. The electronic portal imaging device-based software shows reliable and valid results for point dose and fluence map measurements in phantom studies.
Area of Science:
- Medical Physics
- Radiation Oncology
Background:
- Accurate dosimetry is crucial for effective radiation therapy.
- Electronic portal imaging devices (EPIDs) offer potential for in vivo dosimetry.
- PerFRACTION™ is a novel 3D EPID-based dosimetry software.
Purpose of the Study:
- To validate the PerFRACTION™ software for 3D in vivo dosimetry.
- To evaluate the software's accuracy in measuring point dose and fluence maps.
- To assess PerFRACTION™ performance using phantoms with varying inserts.
Main Methods:
- Three phantoms with different inserts were used for validation.
- Computed tomography simulation and volumetric modulated arc therapy (VMAT) were employed.
- PerFRACTION™ reconstructed doses were compared with ionization chamber and MapCHECK measurements.
Main Results:
- Concordance was observed between ionization chamber and PerFRACTION™ point dose measurements.
- Close agreement was found for dose profiles between PerFRACTION™ and planning system predictions.
- Setup shifts significantly impacted 2D gamma passing rates in PerFRACTION™.
Conclusions:
- PerFRACTION™ demonstrates reliability and validity in experimental phantom conditions.
- The software shows promise for 3D in vivo dosimetry applications.
- Further validation in clinical settings may be warranted.
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