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Updated: Jan 26, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
A comparative study of the physicochemical properties of hesperidin, MTA-Angelus and calcium hydroxide as pulp
Ebtesam O Abo El-Mal1, Ashraf M Abu-Seida2, Salma H El Ashry3
1Department of Endodontics, Faculty of Dental and Oral Surgery, Misr University for Science and Technology, Giza, Egypt.
Aim:
This study compared the setting time, radiopacity, solubility and pH changes between Hisperidin cement, MTA-Angelus and Calcium hydroxide cements.
Methods:
The study was conducted on 3 equal groups of samples of the evaluated capping materials including; Hisperidin (group I, N = 24), MTA-Angelus (group II, N = 24) and Dycal (group III, N = 24). According to the assessed property, these groups were further subdivided into three equal subgroups (8 samples each) including; subgroup A for assessment of the setting time, subgroup B for assessment of radiopacity and subgroup C for assessment of the solubility of the material and evaluation of pH. All recorded data were tabulated and statistically analyzed.
Results:
The highest mean value of setting time was for the MTA-Angelus followed by Hesperidin and Calcium hydroxide with 72.83, 48.26 and 1.58 min, respectively. MTA-Angelus had the highest radiopacity value and followed by Calcium hydroxide then Hesperidin. Hesperidin showed the solubility in distilled water (≈45% mass loss) in relation to Calcium hydroxide (≈19% mass loss). On the other hand, MTA-Angelus showed 9% increase in weight. On contrast to MTA and Calcium hydroxide, Hesperidin showed decrease in pH value throughout the evaluation periods. Higher pH values in MTA-Angelus and Calcium hydroxide were reported in comparison with Hesperidin.
Conclusion:
Despite its slight acidic nature, lower radiopacity and longer initial setting time, Hesperidin, as a natural product, is a promising pulp capping material. Further research on Hesperidin powder is recommended to improve its physicochemical properties and to assess its biological actions.
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