Related Experiment Video

Updated: Jan 26, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

28.7K

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury

Bobbi Fleiss1,2,3, Flora Wong4,5,6, Fiona Brownfoot7

  • 1School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.

Frontiers in Endocrinology
|April 16, 2019
PubMed

Insights

Intrauterine growth restriction (IUGR) poses significant risks for fetal demise and permanent neurological deficits. This review highlights knowledge gaps and emerging technologies to improve neurodevelopmental outcomes in IUGR.

Area of Science:

  • Perinatology
  • Neuroscience
  • Developmental Biology

Background:

  • Intrauterine growth restriction (IUGR) is a major global health concern with significant neurodevelopmental consequences.
  • Despite advances, effective therapies to prevent fetal demise and neurological deficits in IUGR remain limited.

Purpose of the Study:

  • To identify clinical and translational gaps hindering progress in managing IUGR's neurological sequelae.
  • To highlight novel tools, techniques, and technologies for improved understanding and treatment of IUGR.

Main Methods:

  • Review of current research and clinical practices related to IUGR.
  • Discussion of emerging technologies including advanced monitoring, genomic analysis, and nanoparticle-based drug delivery.

Main Results:

  • Gaps exist in understanding IUGR-related inflammation and the need for human post-mortem studies.
  • Integrated histology-imaging analyses offer insights into MRI signal specificity.
  • Genomic analysis and nanoparticle delivery show potential for risk stratification and targeted treatments.

Conclusions:

  • Addressing knowledge gaps in IUGR is crucial for improving neurodevelopmental outcomes.
  • Innovative technologies offer promising avenues for better drug design, delivery, and therapeutic interventions in IUGR.

Keywords:
brain developmentgrowth restrictionneurobiology and brain physiologyneuroinflammationneuroprotection

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.9K
Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection11:44

Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection

Published on: October 3, 2025

1.3K

Related Concept Videos

Emerging Adulthood01:27

Emerging Adulthood

Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
656
Gap Junctions01:37

Gap Junctions

Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.0K
Gap Junctions01:27

Gap Junctions

The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.4K
Restriction Enzymes01:11

Restriction Enzymes

Restriction enzymes are bacterial enzymes used to cut DNA in a sequence-specific manner. To cleave DNA, they bind to specific palindromic sequences called restriction sites. Such palindromic DNA sequences or inverted repeats are commonly found in regions of functional significance, such as the origin of replication, gene operator sites, and regions containing transcription termination signals.
The host bacteria protect their own genomic DNA from these enzymes by methylating these sites. Some...
35.8K
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
325
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.3K