Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparison of two transdermal nitroglycerin systems.

C Godoy, B R Greenspahn, M J Kushner

    Clinical Therapeutics
    |January 1, 1986
    PubMed
    Summary

    Transderm-Nitro (TDN) patches demonstrated superior adherence and patient preference compared to Nitro-Dur II (ND II) patches in a four-week angina pectoris treatment study. TDN patches had significantly less detachment and were preferred by patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    In vitro assessment of the capacity of certain mycotoxin binders to adsorb some amino acids and water-soluble vitamins.

    Journal of dairy science·2020
    Same author

    The impact of different classes of lupus nephritis on maternal and fetal outcomes: a cohort study of 147 pregnancies.

    Lupus·2019
    Same author

    Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study.

    BJOG : an international journal of obstetrics and gynaecology·2018
    Same author

    The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
    Same author

    Gestational outcomes in patients with neuropsychiatric systemic lupus erythematosus.

    Lupus·2017
    Same author

    Lupus and the brain: neuropsychiatric aspects in systemic lupus erythematosus.

    Lupus·2017

    Area of Science:

    • Cardiology
    • Dermatology
    • Pharmacology

    Background:

    • Angina pectoris management often involves transdermal nitroglycerin patches.
    • Comparing different transdermal nitroglycerin formulations is crucial for optimizing patient care.
    • Transderm-Nitro (TDN) and Nitro-Dur II (ND II) are commonly used patches with varying adherence profiles.

    Purpose of the Study:

    • To compare the adherence properties of TDN and ND II patches.
    • To assess patient preference between TDN and ND II patches.
    • To evaluate local side effects associated with both transdermal nitroglycerin patch brands.

    Main Methods:

    • A four-week, eight-site study involving 115 patients with angina pectoris.
    • Patients simultaneously used one TDN and one ND II patch, each delivering half the prescribed daily dose.

    Related Experiment Videos

  • Data collected on patch adherence, patient preference, and application site reactions.

    • Main Results:

    • TDN patches exhibited significantly better adherence, with 98.2% total adherence versus 86.7% for ND II.
    • Fewer TDN patches detached (0.1%) compared to ND II (5%), and fewer became loose (1.7% vs. 8.4%).
    • Patients showed a significant preference for TDN over ND II in four of eight assessed variables, including prescription choice.

    Conclusions:

    • Transderm-Nitro patches offer superior adherence and patient preference compared to Nitro-Dur II patches.
    • These findings suggest TDN may be a more reliable option for transdermal nitroglycerin delivery in angina pectoris.
    • No significant difference in local application site reactions was observed between the two patch types.