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Focusing of Light in the Eye01:16

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Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
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Coping Strategies: Emotion Focused01:20

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Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
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Focus Charting, also known as the focus charting system or "focus documentation," is a systematic documentation approach used in healthcare to organize patient information in medical records.
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Bioengineering Human Microvascular Networks in Immunodeficient Mice
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Microvascular bioengineering: a focus on pericytes.

Huaning Zhao1,2, John C Chappell1,2,3

  • 1Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute, 2 Riverside Circle, Roanoke, VA 24016 USA.

Journal of Biological Engineering
|April 16, 2019
PubMed
Summary
This summary is machine-generated.

Incorporating vascular pericytes into microvascular bioengineering is crucial. These cells enhance the function of engineered microvessels and computational models, accelerating clinical solutions for vascular diseases.

Keywords:
CapillaryComputational modelingEndothelial cellsMicrofluidicsPericytes

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Isolation and Purification of Murine Cardiac Pericytes
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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Physiology

Background:

  • Capillaries are vital for microcirculation, facilitating oxygen and nutrient exchange.
  • Microvascular bioengineering aims to replicate capillary network functions.
  • Vascular pericytes are increasingly recognized as essential components of microvasculature.

Purpose of the Study:

  • To review pericyte identification and function in microvasculature.
  • To discuss the importance of pericytes in bioengineered microvessel platforms.
  • To highlight the role of pericytes in computational models of microcirculation.

Main Methods:

  • Literature review of pericyte biology and bioengineering applications.
  • Analysis of pericyte integration in 3D cultures and microfluidic systems.
  • Examination of pericyte contributions to computational microcirculation models.

Main Results:

  • Pericytes play critical roles in microvascular stability and function.
  • Incorporating pericytes into bioengineered systems improves their physiological relevance.
  • Pericytes enhance the accuracy of computational models for angiogenesis and exchange kinetics.

Conclusions:

  • Vascular pericytes are indispensable for advanced microvascular bioengineering.
  • Integrating pericytes into engineered systems and models boosts their utility.
  • This integration accelerates the clinical translation of microcirculation research for vascular pathologies.