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Using the Threat Probability Task to Assess Anxiety and Fear During Uncertain and Certain Threat

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Published on: September 12, 2014

Hepatitis E: an underestimated emerging threat.

Glynn W Webb¹, Harry R Dalton²

¹University of Manchester NHS Foundation Trust, 7 Radnor Rd London NW6 6TT Manchester, UK.

Therapeutic Advances in Infectious Disease

|April 16, 2019

Summary

This summary is machine-generated.

Hepatitis E virus (HEV) infection is a significant global health issue, causing widespread illness and death. Increased awareness and improved diagnostic methods are crucial for understanding and managing this common cause of viral hepatitis.

Keywords:

emerging disease extrahepatic manifestations hepatitis E neurological injury zoonotic infection

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Area of Science:

Hepatology and Virology
Infectious Diseases and Public Health

Background:

Hepatitis E virus (HEV) is the leading cause of viral hepatitis globally, with millions infected annually.
Previously underestimated in industrialized nations, HEV is now recognized as highly prevalent in developed regions.
Challenges in in vitro study have historically limited understanding of HEV's lifecycle and clinical impact.

Purpose of the Study:

To highlight the underestimated global burden of Hepatitis E virus infection.
To emphasize the need for improved recognition and diagnosis of HEV.
To underscore the importance of understanding HEV's full clinical spectrum and transmission dynamics.

Main Methods:

Review of existing epidemiological data and clinical observations.
Analysis of transmission routes based on HEV genotype and geographic location.
Assessment of diagnostic challenges and clinical under-recognition.

Main Results:

HEV infection is common in industrialized countries, often acquired through zoonotic foodborne transmission.
HEV can cause both acute and chronic infections, with diverse extrahepatic manifestations (neurological, renal, hematological).
Underdiagnosis is frequent due to limited clinician awareness and incomplete understanding of HEV's clinical presentation.

Conclusions:

The true global burden of HEV infection is significantly underestimated.
Enhanced clinical awareness, improved diagnostic tools, and further research into HEV's natural history are essential.
Effective management and reduction of HEV's global impact necessitate better recognition and diagnosis.