Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating monoclonal IgM lambda cryoglobulin with collagen type I affinity in vasculitis.

I Clemmensen, B A Jensen, B Hølund

    Clinical and Experimental Immunology
    |June 1, 1986
    PubMed
    Summary

    A patient with vasculitis developed an IgM lambda cryoglobulinemia that targeted collagen type I. This autoantibody specificity likely contributed to the severe, ultimately fatal, systemic necrotizing vasculitis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Outcome determinants for transformed indolent lymphomas treated with or without autologous stem-cell transplantation.

    Annals of oncology : official journal of the European Society for Medical Oncology·2014
    Same author

    Gene expression in epithelial ovarian cancer: a study of intratumor heterogeneity.

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2007
    Same author

    Prognostic significance of p53, Her-2, and EGFR overexpression in borderline and epithelial ovarian cancer.

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2004
    Same author

    Anagrelide treatment in 52 patients with chronic myeloproliferative diseases.

    Clinical and laboratory haematology·2004
    Same author

    From tobacco to health care and beyond--a critique of lawsuits targeting unpopular industries.

    Cornell law review·2001
    Same author

    cDNA cloning and characterization of a high affinity aryl hydrocarbon receptor in a cetacean, the beluga, Delphinapterus leucas.

    Toxicological sciences : an official journal of the Society of Toxicology·2001

    Area of Science:

    • Immunology
    • Rheumatology
    • Pathology

    Background:

    • Henoch-Schönlein purpura is a common vasculitis, but relapses can indicate underlying systemic disease.
    • Monoclonal cryoglobulinemia, particularly type I, can manifest as systemic vasculitis.
    • Collagen type I is a major structural protein in connective tissues.

    Observation:

    • A 66-year-old male recovered from Henoch-Schönlein purpura, then relapsed with IgM lambda monoclonal cryoglobulinemia.
    • The patient exhibited systemic necrotizing vasculitis with low immune complexes and complement consumption.
    • Treatment with glucocorticoids and plasmapheresis was ineffective.

    Findings:

    • Indirect immunoperoxidase staining revealed cryo-IgM binding to interstitial connective tissue.

    Related Experiment Videos

  • The cryo-IgM specifically localized to areas rich in collagen type I.
  • The patient's IgM lambda was identified as an autoantibody targeting human procollagen type I.

    • Implications:

    • This case suggests a novel autoimmune mechanism in vasculitis, where anti-collagen antibodies trigger systemic inflammation.
    • Understanding this anti-collagen specificity could lead to targeted therapies for similar autoimmune vasculitides.
    • The findings highlight the importance of investigating cryoglobulinemia in relapsing vasculitic syndromes.