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Related Concept Videos

Lung Capacity01:47

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
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Related Experiment Video

Updated: Jan 26, 2026

Isolation of Primary Mouse Lung Endothelial Cells
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Associations between lung and endothelial function in early middle age.

Robert J Hancox1, Lathan Thomas1, Michael J A Williams2

  • 1Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

Respirology (Carlton, Vic.)
|April 16, 2019
PubMed
Summary

Poor lung function, especially lower lung volumes and airflow obstruction, is linked to worse endothelial function in women. This association is weaker in men, suggesting sex differences in cardiovascular disease risk related to lung health.

Keywords:
cohort studiesobstructive lung diseasesrespiratory function testsvascular endotheliumvasodilation

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Area of Science:

  • Cardiovascular Health
  • Pulmonary Medicine
  • Epidemiology

Background:

  • Chronic lung disease is linked to impaired endothelial function, a potential cardiovascular risk factor.
  • The relationship between lung function and endothelial function in the general population is not well understood.

Purpose of the Study:

  • To investigate the association between lung function and endothelial function in a population-based cohort of 38-year-old adults.
  • To explore potential sex differences in this association.

Main Methods:

  • Endothelial function assessed using peripheral arterial tonometry (Framingham reactive hyperemia index).
  • Lung function measured via spirometry, lung volumes, airway conductance, and gas transfer.
  • Regression analyses used to examine associations, adjusting for confounders.

Main Results:

  • Sex significantly modified the lung and endothelial function association.
  • In women, lower spirometry, total lung capacity, and functional residual capacity (FRC) correlated with worse endothelial function, even after adjustments.
  • In men, associations were weaker, with FRC, airway conductance, and FEV1/FVC ratios showing links to endothelial function.

Conclusions:

  • Reduced lung volumes and airflow obstruction are associated with endothelial dysfunction in women.
  • Evidence for a similar association in men is less robust, indicating sex-specific relationships.
  • Findings may partially explain higher cardiovascular disease risk in individuals with poor lung function.