Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Signs of Puberty01:27

Signs of Puberty

1.5K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.5K
Tumor Progression02:07

Tumor Progression

7.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K
Oogenesis02:07

Oogenesis

69.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
69.3K
Cleavage and Blastulation01:33

Cleavage and Blastulation

50.0K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
50.0K
The Nucleolus02:55

The Nucleolus

10.3K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
10.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Respiratory Syncytial Virus.

Pediatric annals·2022
Same author

Diarrhea in Resource-Rich Countries: Common and Uncommon Causes.

Pediatric annals·2022
Same author

Overview of the Updates for the Management of Asthma Guidelines.

Pediatric annals·2022
Same author

Molluscum and Tinea and Warts, Oh My!

Pediatric annals·2022
Same author

The Changing Face of Bullying and What We Can Do to Stop It.

Pediatric annals·2021
Same author

Polycystic Ovarian Syndrome in Adolescents: Keys to Diagnosis and Management.

Pediatric annals·2021

Related Experiment Video

Updated: Jan 26, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

14.6K

Puberty: Onset and Progression.

Leah Khan

    Pediatric Annals
    |April 16, 2019
    PubMed
    Summary

    Understanding normal and abnormal puberty is crucial for pediatric healthcare providers. This review covers typical pubertal development, delayed puberty, and premature puberty, aiding in patient counseling and timely intervention.

    Area of Science:

    • Pediatric Endocrinology
    • Adolescent Medicine
    • Hormonal Regulation

    Background:

    • Puberty is a critical developmental stage in children and adolescents.
    • Healthcare providers need to be comfortable discussing pubertal changes.
    • Normal puberty involves complex hormonal pathways.

    Purpose of the Study:

    • To review the typical pubertal pathway.
    • To discuss the common causes of delayed and premature puberty.
    • To equip healthcare providers to counsel patients and identify abnormal development.

    Main Methods:

    • Review of current literature on pubertal development.
    • Analysis of hormonal pathways involved in puberty.
    • Compilation of common causes and initial testing for abnormal puberty.

    More Related Videos

    Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
    06:38

    Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

    Published on: October 13, 2018

    16.3K
    Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
    09:25

    Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

    Published on: June 28, 2013

    27.5K

    Related Experiment Videos

    Last Updated: Jan 26, 2026

    A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
    09:59

    A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

    Published on: September 16, 2017

    14.6K
    Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
    06:38

    Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

    Published on: October 13, 2018

    16.3K
    Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
    09:25

    Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

    Published on: June 28, 2013

    27.5K

    Main Results:

    • Normal puberty follows a predictable sequence driven by hormonal signals.
    • Delayed puberty can result from various factors affecting hormonal pathways.
    • Premature puberty involves early onset of secondary sexual characteristics due to hormonal disruption.

    Conclusions:

    • Familiarity with normal and abnormal puberty is essential for pediatric care.
    • Early identification and understanding of pubertal variations allow for appropriate monitoring and intervention.
    • This knowledge empowers providers to manage physical and psychological implications of pubertal timing.